Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced
liver injury often assume that the biomarker is released passively from dying cells. However …

Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in
humans. A precondition for improved strategies to disrupt and/or reverse the damage is a …

Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in
mice often serves as a model for drug-induced liver injury in humans. By specifying that …

In silico approaches have been proposed as a novel strategy to increase the repertoire of
clinical trial designs. Realistic simulations of clinical trials can provide valuable information …

Previous studies reported that sea buckthorn (Hippophae rhamnoides L., Elaeagnaceae,
HRP) exhibits hepatoprotective effects via its anti-inflammatory and antioxidant properties as …

ABSTRACT A virtual biomedical experiment (VBE) is a simulation of a wet-lab or clinical
biomedical experiment. The goal of VBEs is to provide a scientifically useful method of in …

A significant portion of bone fractures fail to heal properly, increasing healthcare costs.
Advances in fracture management have slowed because translation barriers have limited …

11.1 Introduction kk When a drug development effort fails or is abandoned, one or more
contributing factors can often be traced to flawed explanatory mechanistic insight into often …

Predictions of xenobiotic hepatic clearance in humans using in vitro-to-in vivo extrapolation
methods are frequently inaccurate and problematic. Multiple strategies are being pursued to …

We demonstrate how results of virtual experiments can suggest mechanism-based
explanations for IVIVE underpredictions of hepatic clearance. We use agent-oriented …