The impact of inspiratory flow rate on drug delivery to the lungs with dry powder inhalers
J Weers, A Clark - Pharmaceutical research, 2017 - Springer
Current marketed dry powder inhalers utilize the energy from patient inspiration to fluidize
and disperse bulk powder agglomerates into respirable particles. Variations in patient …
and disperse bulk powder agglomerates into respirable particles. Variations in patient …
Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung
Abstract Development of a new drug for the treatment of lung disease is a complex and time
consuming process involving numerous disciplines of basic and applied sciences. During …
consuming process involving numerous disciplines of basic and applied sciences. During …
Exhaled aerosol increases with COVID-19 infection, age, and obesity
DA Edwards, D Ausiello, J Salzman… - Proceedings of the …, 2021 - National Acad Sciences
COVID-19 transmits by droplets generated from surfaces of airway mucus during processes
of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 …
of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 …
Recent developments in the computational simulation of dry powder inhalers
J Capecelatro, W Longest, C Boerman… - Advanced Drug Delivery …, 2022 - Elsevier
This article reviews recent developments in computational modeling of dry powder inhalers
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …
Numerical study on the effect of the realistic mouth-inhaler positions on orally inhaled drug delivery in pediatric intersubject upper airways
The relative position between the pediatric upper airway and the inhalation device during
real inhalation administration has significant effects on the delivery efficiency of orally …
real inhalation administration has significant effects on the delivery efficiency of orally …
A whole lung in silico model to estimate age dependent particle dosimetry
Anatomical and physiological changes alter airflow characteristics and aerosol distribution
in the developing lung. Correlation between age and aerosol dosimetry is needed …
in the developing lung. Correlation between age and aerosol dosimetry is needed …
High-efficiency dry powder aerosol delivery to children: Review and application of new technologies
While dry powder aerosol formulations offer a number of advantages, their use in children is
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols
In vitro-in vivo correlation is the establishment of a predictive relationship between in vitro
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …
Experimental investigation of aerosol deposition through a realistic respiratory airway replica: an evaluation for MDI and DPI performance
K Ahookhosh, S Yaqoubi… - International journal of …, 2019 - Elsevier
Purpose In the present work, a comparison between MDI and DPI for evaluating
performance of the devices were carried out by experimentally investigating the deposition …
performance of the devices were carried out by experimentally investigating the deposition …
In Vitro–In Vivo Correlations Observed With Indacaterol-Based Formulations Delivered with the Breezhaler®
Background: Establishing robust in vitro–in vivo correlations (IVIVC) between aerosol
performance, pharmacokinetics, and clinical efficacy is critical in developing bioequivalent …
performance, pharmacokinetics, and clinical efficacy is critical in developing bioequivalent …