Anticancer activity of curcumin and its analogues: preclinical and clinical studies
Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-
inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides …
inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides …
Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents
S Saeed, N Rashid, PG Jones, M Ali… - European journal of …, 2010 - Elsevier
Five series of thiourea derivatives bearing benzothiazole moiety (20 compounds) were
efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results …
efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results …
1, 5-diaryl-3-oxo-1, 4-pentadienes: a case for antineoplastics with multiple targets
U Das, RK Sharma, JR Dimmock - Current medicinal chemistry, 2009 - ingentaconnect.com
A number of organic molecules which contain the 1, 5-diaryl-3-oxo-1, 4-pentadienyl group,
referred to hereafter as the dienone moiety, have antineoplastic properties. Emphasis is …
referred to hereafter as the dienone moiety, have antineoplastic properties. Emphasis is …
Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents
A novel series of optically active 2-aminobenzothiazole derivatives were synthesized by
reaction of optically active amine (I) with thiophosgene to obtain optically active …
reaction of optically active amine (I) with thiophosgene to obtain optically active …
[HTML][HTML] Synthesis, characterization and anticancer activity of certain 3-{4-(5-mercapto-1, 3, 4-oxadiazole-2-yl) phenylimino} indolin-2-one derivatives
R Gudipati, RNR Anreddy, S Manda - Saudi Pharmaceutical Journal, 2011 - Elsevier
Abstract A series of 5-or 7-substituted 3-{4-(5-mercapto-1, 3, 4-oxadiazol-2-yl) phenylimino}-
indolin-2-one derivatives were synthesized by treating 5-(4-aminophenyl)-1, 3, 4-oxadiazole …
indolin-2-one derivatives were synthesized by treating 5-(4-aminophenyl)-1, 3, 4-oxadiazole …
Exploring highly functionalized tetrahydropyridine as a dual inhibitor of monoamine oxidase A and B: synthesis, structural analysis, single crystal XRD, supramolecular …
Ethyl 4-(4-fluorophenylamino)-2, 6-bis (4-(trifluoromethyl) phenyl)-1-(4-fluoro-phenyl)-1, 2, 5,
6-tetrahydropyridine-3-carboxylate (FTEAA) has been synthesized efficiently in an iodine …
6-tetrahydropyridine-3-carboxylate (FTEAA) has been synthesized efficiently in an iodine …
CLEFMA—An anti-proliferative curcuminoid from structure–activity relationship studies on 3, 5-bis (benzylidene)-4-piperidones
3, 5-Bis (benzylidene)-4-piperidones are being advanced as synthetic analogs of curcumin
for anti-cancer and anti-inflammatory properties. We performed structure–activity …
for anti-cancer and anti-inflammatory properties. We performed structure–activity …
Multicomponent reaction–derived covalent inhibitor space
The area of covalent inhibitors is gaining momentum due to recently introduced clinical
drugs, but libraries of these compounds are scarce. Multicomponent reaction (MCR) …
drugs, but libraries of these compounds are scarce. Multicomponent reaction (MCR) …
An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents
We have demonstrated a novel and green approach for the synthesis of 2-substituted
benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were …
benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were …
Regioselective synthesis and stereochemical structure of anti-tumor active dispiro [3H-indole-3, 2′-pyrrolidine-3′, 3 ″-piperidine]-2 (1H), 4 ″-diones
AS Girgis - European journal of medicinal chemistry, 2009 - Elsevier
Reaction of 3, 5-bis (arylmethylene)-1-methyl-4-piperidinones 1a–1g with azomethine ylides
(generated in situ via decarboxylative condensation of isatins 2a, 2b with sarcosine 3) in …
(generated in situ via decarboxylative condensation of isatins 2a, 2b with sarcosine 3) in …