Mitochondria are critical organelles for endocrine health; steroid hormone biosynthesis
occurs in these organelles and they provide energy in the form of ATP for hormone …

Whereas it is now more than 150 yr since T. Addison first described the clinical and
pathological features of adrenal failure, the disease remains underdiagnosed, leading to …

Adrenal insufficiency is an insidious diagnosis that can be initially misdiagnosed as other life-
threatening endocrine conditions, as well as sepsis, metabolic disorders, or cardiovascular …

We evaluated the coenzyme Q₁₀ (CoQ) levels in patients who were diagnosed with
mitochondrial oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders (n= 72) …

Abstract Objective Single Large Scale Mitochondrial DNA Deletions (SLSMDs), Pearson
Syndrome (PS) and Kearns-Sayre Syndrome (KSS), are systemic diseases with multiple …

Background Electrolyte reabsorption in the kidney has a high energy demand. Proximal and
distal tubular epithelial cells have a high mitochondrial density for energy release. Recently …

Cortisol is central to several homeostatic mechanisms including the stress and immune
response. Adrenal insufficiency and impaired cortisol production leads to severe, potentially …

Post-traumatic stress disorder remains the most significant psychiatric condition associated
with exposure to a traumatic event, though rates of traumatic event exposure far outstrip …

Chronic glucocorticoid excess directly causes muscle weakness. Muscle wasting in
Cushing's disease reverses if the glucocorticoid levels are normalized. 105 Patients …

From the first description by Kearns and Sayre in 1958, this syndrome has been diagnosed
in several hundred patients. However, the labile character of its clinical manifestations …