HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022 - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

The changing therapeutic landscape of head and neck cancer

JD Cramer, B Burtness, QT Le, RL Ferris - Nature reviews Clinical …, 2019 - nature.com
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …

Phase II randomized trial of transoral surgery and low-dose intensity modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: an ECOG …

RL Ferris, Y Flamand, GS Weinstein, S Li… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE Definitive or postoperative chemoradiation (CRT) is curative for human
papillomavirus–associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity …

Photodynamic therapy in oral cancer: A review of clinical studies

SA Mosaddad, RA Namanloo, SS Aghili, P Maskani… - Medical Oncology, 2023 - Springer
A significant mortality rate is associated with oral cancer, particularly in cases of late-stage
diagnosis. Since the last decades, oral cancer survival rates have only gradually improved …

Carcinogenic human papillomavirus infection

M Schiffman, J Doorbar, N Wentzensen… - Nature reviews Disease …, 2016 - nature.com
Infections with human papillomavirus (HPV) are common and transmitted by direct contact.
Although the great majority of infections resolve within 2 years, 13 phylogenetically related …

Management of the neck in squamous cell carcinoma of the oral cavity and oropharynx: ASCO clinical practice guideline

SA Koyfman, N Ismaila, D Crook, A D'Cruz… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE The aim of the current work is to provide evidence-based recommendations to
practicing physicians and others on the management of the neck in patients with squamous …

Oropharyngeal carcinoma with a special focus on HPV-related squamous cell carcinoma

RL Ferris, W Westra - Annual Review of Pathology: Mechanisms …, 2023 - annualreviews.org
Human papillomavirus–positive oropharyngeal squamous cell carcinoma (HPV-OPSCC)
has one of the most rapidly increasing incidences of any cancer in high-income countries …

Head and neck cancer: improving outcomes with a multidisciplinary approach

C Lo Nigro, N Denaro, A Merlotti… - Cancer management and …, 2017 - Taylor & Francis
For early-stage head and neck cancer (HNC), surgery (S) or radiotherapy (RT) is a standard
treatment. The multidisciplinary approach, which includes multimodality treatment with S …

Optimizing treatment de‐escalation in head and neck cancer: current and future perspectives

AJ Rosenberg, EE Vokes - The oncologist, 2021 - academic.oup.com
Abstract Treatment of locoregionally advanced head and neck squamous cell carcinoma
involves a multidisciplinary approach that combines surgery, radiotherapy, and systemic …

Mature results of a prospective study of deintensified chemoradiotherapy for low‐risk human papillomavirus‐associated oropharyngeal squamous cell carcinoma

BS Chera, RJ Amdur, JE Tepper, X Tan, J Weiss… - Cancer, 2018 - Wiley Online Library
BACKGROUND The purpose of the current study was to determine quality of life and tumor
control from a prospective phase 2 clinical trial evaluating deintensified chemoradiotherapy …