Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The …

Autoinflammatory diseases are associated with abnormal activation of the innate immune
system, leading to clinical inflammation and high levels of acute-phase reactants. The first …

Summary Familial Mediterranean Fever (FMF) is the oldest and the most frequent of all
described hereditary periodic fever syndromes. The populations originating from …

Familial autoinflammatory diseases: genetics, pathogenesis a... : Current Opinion in
Rheumatology Familial autoinflammatory diseases: genetics, pathogenesis and treatment …

Familial Mediterranean fever is inherited in an autosomal recessive manner. There are two
phenotypes: types 1 and 2. Familial Mediterranean fever type 1 is characterized by recurrent …

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease that is
prevalent in Mediterranean populations. While it is considered a rare disease in the rest of …

Abstract Introduction Familial Mediterranean fever (FMF) is a hereditary autoinflammatory
disease characterized by recurrent self-limiting fever and serositis that mainly affects …

Objectives Familial Mediterranean fever (FMF) is caused by mutations in MEFV, which
encodes pyrin. The nature of substitutions P369S and R408Q in exon 3 remains unclear …

The aim of this study was to determine the relationship between clinical findings and the
most common mutated alleles of MEFV gene in a childhood population and to determine the …