Biomarkers of aging

Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Dietary regulations for microbiota dysbiosis among post-menopausal women with type 2 diabetes

V Singh, YJ Park, GD Lee, T Unno… - Critical Reviews in Food …, 2023 - Taylor & Francis
Abstract Type 2 diabetes (T2D) and T2D-associated comorbidities, such as obesity, are
serious universally prevalent health issues among post-menopausal women. Menopause is …

Pathophysiology of type 2 diabetes in sub-Saharan Africans

JH Goedecke, AE Mendham - Diabetologia, 2022 - Springer
Abstract Sub-Saharan Africa (SSA) is the region with the highest projected rates of increase
in type 2 diabetes (129% by 2045), which will exacerbate the already high prevalence of …

Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function

AE Mendham, S Larsen, C George, K Adams… - Scientific Reports, 2020 - nature.com
We assessed differences in mitochondrial function in gluteal (gSAT) and abdominal
subcutaneous adipose tissue (aSAT) at baseline and in response to 12-weeks of exercise …

Adipocyte heterogeneity underlying adipose tissue functions

Z Yang Loureiro, J Solivan-Rivera, S Corvera - Endocrinology, 2022 - academic.oup.com
Adipose tissue distribution in the human body is highly heterogeneous, and the relative
mass of different depots is differentially associated with metabolic disease risk. Distinct …

Pathogenesis of type 2 diabetes risk in black Africans: a South African perspective

JH Goedecke, T Olsson - Journal of Internal Medicine, 2020 - Wiley Online Library
The prevalence of type 2 diabetes (T2D) is higher in black Africans than their European
counterparts. This review summarizes the research exploring the pathogenesis of T2D in …

Waist circumference thresholds predicting incident dysglycaemia and type 2 diabetes in Black African men and women

JH Goedecke, KA Nguyen, C Kufe… - Diabetes, Obesity …, 2022 - Wiley Online Library
Aims To determine the waist circumference (WC) thresholds for the prediction of incident
dysglycaemia and type 2 diabetes (T2D) in Black South African (SA) men and women and to …

Increased risk for type 2 diabetes in relation to adiposity in middle-aged black South African men compared to women

CN Kufe, LK Micklesfield, M Masemola… - European journal of …, 2022 - academic.oup.com
Aims Despite a higher prevalence of overweight/obesity in Black South African women
compared to men, the prevalence of type 2 diabetes (T2D) does not differ. We explored if …

Chemerin influences blood lipid of aged male mice under high fat diet and exercise states through regulating the distribution and browning of white adipose tissue

J Qu, S Fu, L Yin, Q Zhang, X Wang - Cytokine, 2024 - Elsevier
Background With aging, white adipose tissue (WAT) undergoes distribution change and
browning inhibition, which could be attenuated by exercise. Adipokine chemerin exerts roles …

Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women

M Masemola, AE Mendham… - The Journal of …, 2025 - academic.oup.com
Objective To explore depot-specific functional aspects of adipose tissue, examining the
putative role for menopause and HIV status on insulin sensitivity (SI) and beta-cell function …