The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Bone cells compose a population of cells of heterogeneous origin but restricted function with
respect to matrix formation, mineralization, and resorption. The local, mesenchymal origin of …

Exploring the basic mechanical principles of bone-related research and mechanical testing
of bone specimens, this book has 42 chapters divided into three major sections that cover …

THIS year marks the 70th anniversary of the discovery of alkaline phosphatase (ALP)(1). For
the greater part of the past seven decades there has been universal appreciation by …

A review and discussion of new knowledge on the structure and function of mammalian
alkaline phosphatases (APs) gained over the last 25 years. It covers:* The structure …

Bone mineralization is initiated by matrix vesicles, small extracellular vesicles secreted by
osteoblasts, inducing the nucleation and subsequent growth of calcium phosphate crystals …

We have developed methodology that enables alkaline phosphatase (ALP) to be
histochemically stained reproducibly in decalcified paraffin-embedded bone and cartilage of …

The objective of this study was to evaluate the effects of metal ions, which may be released
from orthopedic or dental implants, on osteoblast metabolism and differentiation. ROS 17/2.8 …

Publisher Summary Hypophosphatasia is the rare, heritable form of rickets or osteomalacia
that features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) …

The human tissue nonspecific alkaline phosphatase (TNAP) is found in liver, kidney, and
bone. Mutations in the TNAP gene can lead to Hypophosphatasia, a rare inborn disease that …