[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Machine learning-enabled retrobiosynthesis of molecules

T Yu, AG Boob, MJ Volk, X Liu, H Cui, H Zhao - Nature Catalysis, 2023 - nature.com
Retrobiosynthesis provides an effective and sustainable approach to producing functional
molecules. The past few decades have witnessed a rapid expansion of biosynthetic …

BRENDA, the ELIXIR core data resource in 2021: new developments and updates

A Chang, L Jeske, S Ulbrich, J Hofmann… - Nucleic acids …, 2021 - academic.oup.com
The BRENDA enzyme database (https://www. brenda-enzymes. org), established in 1987,
has evolved into the main collection of functional enzyme and metabolism data. In 2018 …

The IntAct database: efficient access to fine-grained molecular interaction data

N Del Toro, A Shrivastava, E Ragueneau… - Nucleic acids …, 2022 - academic.oup.com
The IntAct molecular interaction database (https://www. ebi. ac. uk/intact) is a curated
resource of molecular interactions, derived from the scientific literature and from direct data …

BIOPEP-UWM database of bioactive peptides: Current opportunities

P Minkiewicz, A Iwaniak, M Darewicz - International journal of molecular …, 2019 - mdpi.com
The BIOPEP-UWM™ database of bioactive peptides (formerly BIOPEP) has recently
become a popular tool in the research on bioactive peptides, especially on these derived …

Structure-based protein function prediction using graph convolutional networks

V Gligorijević, PD Renfrew, T Kosciolek… - Nature …, 2021 - nature.com
The rapid increase in the number of proteins in sequence databases and the diversity of
their functions challenge computational approaches for automated function prediction. Here …

A comprehensive insight into fungal enzymes: Structure, classification, and their role in mankind's challenges

H El-Gendi, AK Saleh, R Badierah, EM Redwan… - Journal of Fungi, 2021 - mdpi.com
Enzymes have played a crucial role in mankind's challenges to use different types of
biological systems for a diversity of applications. They are proteins that break down and …

Review on natural products databases: where to find data in 2020

M Sorokina, C Steinbeck - Journal of cheminformatics, 2020 - Springer
Natural products (NPs) have been the centre of attention of the scientific community in the
last decencies and the interest around them continues to grow incessantly. As a …

Opportunities and challenges of using metagenomic data to bring uncultured microbes into cultivation

S Liu, CD Moon, N Zheng, S Huws, S Zhao, J Wang - Microbiome, 2022 - Springer
Although there is now an extensive understanding of the diversity of microbial life on earth
through culture-independent metagenomic DNA sequence analyses, the isolation and …

Machine learning in enzyme engineering

S Mazurenko, Z Prokop, J Damborsky - ACS Catalysis, 2019 - ACS Publications
Enzyme engineering plays a central role in developing efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …