The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Covering: 2000 to 2015 Despite a pervasive decline in natural product research at many
pharmaceutical companies over the last two decades, natural products have undeniably …

The spread of antimicrobial resistance has become a serious public health concern, making
once-treatable diseases deadly again and undermining the achievements of modern …

Drug synergy allows a therapeutic effect to be achieved with lower doses of component
drugs. Drug synergy can result when drugs target the products of genes that act in parallel …

Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …

Combinatorial drug treatment strategies perturb biological networks synergistically to
achieve therapeutic effects and represent major opportunities to develop advanced …

Rapidly spreading antibiotic resistance and the low discovery rate of new antimicrobial
compounds demand more effective strategies for early drug discovery. One bottleneck in the …

The antibacterial properties of sodium bicarbonate have been known for years, yet the
molecular understanding of its mechanism of action is still lacking. Utilizing chemical …

Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically,
despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …

Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …