Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Retinal damage in teleosts, unlike mammals, induces robust Müller glia-mediated
regeneration of lost neurons. We examined whether Notch signaling regulates Müller glia …

Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor
loss, which induces concomitant changes in the neural retina, one of the most striking being …

Progressive and irreversible vision loss in mature and aging adults creates a health and
economic burden, worldwide. Despite the advancements of many contemporary therapies to …

Damage to the zebrafish retina stimulates resident Müller glia to reprogram, reenter the cell
cycle, divide asymmetrically, and produce neuronal progenitor cells that amplify and …

In contrast to mammals, zebrafish posses the remarkable ability to regenerate retinal
neurons. Damage to the zebrafish retina induces Müller glia to act as stem cells, generating …

Reactive astrocytes are typically studied in models that cause irreversible mechanical
damage to axons, neuronal cell bodies, and glia. Here, we evaluated the response of …

Müller glia are the primary glial subtype in the retina and perform a wide range of
physiological tasks in support of retinal function, but little is known about the transcriptional …

The mechanisms limiting neuronal regeneration in mammals and their relationship with
reactive gliosis are unknown. Müller glia (MG), common to all vertebrate retinas, readily …

The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These
axons are distributed in an organized pattern from the soma of the RGC to the lateral …