Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Rheumatoid arthritis (RA) is an inflammatory disease characterized by a variety of symptoms
and pathologies often presenting with polyarthritis. The primary symptom in the initial stage …

Due to the increasing antibiotic resistance and the lack of broad-spectrum antibiotics, there
is an urgent requirement to develop fresh strategies to combat multidrug-resistant …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …

Rosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular
mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female …

Macrophages are widely distributed throughout various tissues of the body, and mounting
evidence suggests their involvement in regulating the tissue microenvironment, thereby …

Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human
disease, which distinguishes the condition from most fibrotic diseases that are progressive …

Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles
in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts …

Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has
identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T …

Chronic kidney disease (CKD) is a public health problem driven by myofibroblast
accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized …