Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
Stereoselective amino acid synthesis by synergistic photoredox-pyridoxal radical biocatalysis
Developing synthetically useful enzymatic reactions that are not known in biochemistry and
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …
organic chemistry is an important challenge in biocatalysis. Through the synergistic merger …
Total Heterologous Biosynthesis of Fungal Natural Products in Aspergillus nidulans
Fungal natural products comprise a wide range of bioactive compounds including important
drugs and agrochemicals. Intriguingly, bioinformatic analyses of fungal genomes have …
drugs and agrochemicals. Intriguingly, bioinformatic analyses of fungal genomes have …
Genome mining for unknown–unknown natural products
DA Yee, K Niwa, B Perlatti, M Chen, Y Li… - Nature chemical …, 2023 - nature.com
Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …
β-NAD as a building block in natural product biosynthesis
Abstratct β-Nicotinamide adenine dinucleotide (β-NAD) is a pivotal metabolite for all living
organisms and functions as a diffusible electron acceptor and carrier in the catabolic arms of …
organisms and functions as a diffusible electron acceptor and carrier in the catabolic arms of …
A pyridoxal 5′-phosphate-dependent Mannich cyclase
Abstract Pyridoxal 5′-phosphate (PLP)-dependent enzymes catalyse a diverse range of
chemical transformations. Despite their extraordinary functional diversity, no PLP-dependent …
chemical transformations. Despite their extraordinary functional diversity, no PLP-dependent …
The structural basis of pyridoxal-5′-phosphate-dependent β-NAD-alkylating enzymes
SbzP is a unique pyridoxal-5′-phosphate-dependent enzyme, which catalyses a [3+ 2]
annulation between the pyridinium ring of β-nicotinamide adenine dinucleotide (β-NAD) and …
annulation between the pyridinium ring of β-nicotinamide adenine dinucleotide (β-NAD) and …
Discovery of a polyketide carboxylate phytotoxin from a polyketide glycoside hybrid by β-glucosidase mediated ester bond hydrolysis
X Wang, DK Kong, HR Zhang, Y Zou - Chemical Science, 2024 - pubs.rsc.org
Fungal phytotoxins cause significant harm to agricultural production or lead to plant
diseases. Discovering new phytotoxins, dissecting their formation mechanism and …
diseases. Discovering new phytotoxins, dissecting their formation mechanism and …
Antifungal activity of volatile compounds generated by endophytic fungi Sarocladium brachiariae HND5 against Fusarium oxysporum f. sp. cubense
Y Yang, Y Chen, J Cai, X Liu, G Huang - PloS one, 2021 - journals.plos.org
The soil-born filamentous fungal pathogen Fusarium oxysporum f. sp. cubense (FOC), which
causes vascular wilt disease in banana plants, is one of the most economically important …
causes vascular wilt disease in banana plants, is one of the most economically important …
[HTML][HTML] Virulence factors of the genus Fusarium with targets in plants
A Gutiérrez-Sánchez, J Plasencia… - Microbiological …, 2023 - Elsevier
Fusarium spp. comprise various species of filamentous fungi that cause severe diseases in
plant crops of both agricultural and forestry interest. These plant pathogens produce a wide …
plant crops of both agricultural and forestry interest. These plant pathogens produce a wide …