The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Gastrointestinal motility research is progressing rapidly, leading to significant advances in
the last 15 years in understanding the cellular mechanisms underlying motility, following the …

Abstract Calcium (Ca 2+) signals have a crucial role in regulating various processes of
almost every cell to maintain its structure and function. Calcium dynamics has been studied …

A Ca2+ signaling model is proposed to consider the crosstalk of Ca2+ ions between
endoplasmic reticulum (ER) and mitochondria within microdomains around inositol 1, 4, 5 …

Acidic organelles form an important intracellular Ca2+ pool that can drive global Ca2+
signals through coupling with endoplasmic reticulum (ER) Ca2+ stores. Recently identified …

The stomach is extensively innervated by the vagus nerve and the enteric nervous system.
The mechanisms through which this innervation affects gastric motility are being unraveled …

The intestine comprises a long hollow muscular tube organized in anatomically and
functionally discrete compartments, which digest and absorb nutrients and water from …

Experimental progress in investigating normal and disordered gastric motility is increasingly
being complimented by sophisticated multiscale modeling studies. Mathematical modeling …

Interstitial cells of Cajal (ICC) act as pacemaker cells in the gastrointestinal tract by
generating electrical slow waves to regulate rhythmic smooth muscle contractions. Intrinsic …