Stem cells and the impact of ROS signaling
CL Bigarella, R Liang, S Ghaffari - Development, 2014 - journals.biologists.com
An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …
function during both early development and tissue homeostasis throughout life. Recent …
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Autophagy is a catabolic pathway by which cellular components are delivered to the
lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality …
lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality …
[HTML][HTML] Regulation of stem cell fate by ROS-mediated alteration of metabolism
Stem cells have attracted much attention due to their distinct features that support infinite self-
renewal and differentiation into the cellular derivatives of three lineages. Recent studies …
renewal and differentiation into the cellular derivatives of three lineages. Recent studies …
Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways
SM Rothenberg, K Concannon, S Cullen, G Boulay… - Elife, 2015 - elifesciences.org
Treatment of EGFR-mutant lung cancer with erlotinib results in dramatic tumor regression
but it is invariably followed by drug resistance. In characterizing early transcriptional …
but it is invariably followed by drug resistance. In characterizing early transcriptional …
An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates
Intestinal smooth muscle cells (iSMCs) are a crucial component of the adult gastrointestinal
tract and support intestinal differentiation, peristalsis and epithelial homeostasis during …
tract and support intestinal differentiation, peristalsis and epithelial homeostasis during …
Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells
R Liang, P Rimmelé, CL Bigarella, S Yalcin, S Ghaffari - Cell cycle, 2016 - Taylor & Francis
ABSTRACT Transcription factors FOXOs (1, 3, 4) are essential for the maintenance of
haematopoietic stem cells. FOXOs are evolutionary conserved substrates of the AKT serine …
haematopoietic stem cells. FOXOs are evolutionary conserved substrates of the AKT serine …