Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Biological functions and current advances in isolation and detection strategies for exosome nanovesicles

K Boriachek, MN Islam, A Möller, C Salomon… - Small, 2018 - Wiley Online Library
Abstract Exosomes are nanoscale (≈ 30–150 nm) extracellular vesicles of endocytic origin
that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific …

Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Clinical significance of extracellular vesicles in plasma from glioblastoma patients

D Osti, M Del Bene, G Rappa, M Santos… - Clinical Cancer …, 2019 - AACR
Purpose: Glioblastoma (GBM) is the most common primary brain tumor. The identification of
blood biomarkers reflecting the tumor status represents a major unmet need for optimal …

Exosomal miRNAs as cancer biomarkers and therapeutic targets

A Thind, C Wilson - Journal of extracellular vesicles, 2016 - Taylor & Francis
Intercommunication between cancer cells and with their surrounding and distant
environments is key to the survival, progression and metastasis of the tumour. Exosomes …

Apoptotic cell-derived extracellular vesicles promote malignancy of glioblastoma via intercellular transfer of splicing factors

MS Pavlyukov, H Yu, S Bastola, M Minata, VO Shender… - Cancer cell, 2018 - cell.com
Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells
adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic …

Radiation therapy-induced remodeling of the tumor immune microenvironment

M Charpentier, S Spada, SJ Van Nest… - Seminars in Cancer …, 2022 - Elsevier
The tumor immune microenvironment is a determinant of response to cancer
immunotherapy and, in many cases, is prognostic for patient survival independently of the …

Therapy resistance mediated by exosomes

TB Steinbichler, J Dudás, S Skvortsov, U Ganswindt… - Molecular cancer, 2019 - Springer
Therapy resistance can arise within tumor cells because of genetic or phenotypic changes
(intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment …

Glioblastoma: exosome and microRNA as novel diagnosis biomarkers

L Saadatpour, E Fadaee, S Fadaei… - Cancer gene …, 2016 - nature.com
Glioblastoma (GBM) is known as a tumor type, which arises from astrocytes. Several studies
indicated that GBM tumor cells are malignant. This is because of the fact that they consist of …

Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic?

L Gangoda, S Boukouris, M Liem, H Kalra… - …, 2015 - Wiley Online Library
Extracellular vesicles (EVs) are signaling organelles that are released by many cell types
and is highly conserved in both prokaryotes and eukaryotes. Based on the mechanism of …