Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

Forces that are associated with blood flow are major determinants of vascular
morphogenesis and physiology. Blood flow is crucial for blood vessel development during …

Summary The Polycystic Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …

Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs
develop in many different ways and generate tubes of widely varying sizes and structures …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end
stage renal disease characterized by progressive expansion of kidney cysts. To better …

The primary cilium has evolved as a multifunctional cellular compartment that decorates
most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular …