Unraveling the interplay between unicellular parasites and bacterial biofilms: implications for disease persistence and antibiotic resistance

E Zanditenas, S Ankri - Virulence, 2024 - Taylor & Francis
Bacterial biofilms have attracted significant attention due to their involvement in persistent
infections, food and water contamination, and infrastructure corrosion. This review delves …

Lignin–cellulose complexes derived from agricultural wastes for combined antibacterial and tissue engineering scaffolds for cutaneous leishmaniasis wounds

MAL Huët, IC Phul, N Goonoo, Z Li, X Li… - Journal of Materials …, 2024 - pubs.rsc.org
Bacterial infections in wounds significantly impair the healing process. The use of natural
antibacterial products over synthetic antibiotics has emerged as a new trend to address …

Prokaryotic and eukaryotic skin microbiota modifications triggered by Leishmania infection in localized Cutaneous Leishmaniasis

J Jaimes, LH Patiño, G Herrera, C Cruz… - PLOS Neglected …, 2024 - journals.plos.org
Cutaneous Leishmaniasis (CL) is a tropical disease characterized by cutaneous ulcers,
sometimes with satellite lesions and nodular lymphangitis. Leishmania parasites …

Possible clinical implications and future directions of managing bacterial biofilms in cutaneous leishmaniasis wounds

TDJ Kaluarachchi, PM Campbell… - Tropical Medicine and …, 2022 - Springer
Cutaneous leishmaniasis (CL) lesions are chronic and result in disfiguring scars. The
microbiological aspects of these wounds have not been systematically investigated. We …

Designing of a new multi-epitope vaccine against Leishmania major using Leish-F1 epitopes: An In-silico study

M Rabienia, N Mortazavidehkordi, Z Roudbari… - Plos one, 2024 - journals.plos.org
Cutaneous leishmaniasis (CL) is the most common form of the disease which can cause
malignant lesions on the skin. Vaccination for the prevention and treatment of leishmaniasis …

Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity

C Farias Amorim, VM Lovins, TP Singh… - Science translational …, 2023 - science.org
Leishmania braziliensis is a parasitic infection that can result in inflammation and skin injury
with highly variable and unpredictable clinical outcomes. Here, we investigated the potential …

The sphingolipids ceramide and inositol phosphorylceramide protect the Leishmania major membrane from sterol-specific toxins

CS Haram, S Moitra, R Keane, FM Kuhlmann… - Journal of Biological …, 2023 - ASBMB
The accessibility of sterols in mammalian cells to exogenous sterol-binding agents has been
well-described previously, but sterol accessibility in distantly related protozoa is unclear. The …

Effect of Clindamycin on Intestinal Microbiome and Miltefosine Pharmacology in Hamsters Infected with Leishmania infantum

AI Olías-Molero, P Botías, M Cuquerella… - Antibiotics, 2023 - mdpi.com
Visceral leishmaniasis (VL), a vector-borne parasitic disease caused by Leishmania
donovani and L. infantum (Kinetoplastida), affects humans and dogs, being fatal unless …

Generation of dysbiotic microbiota in cutaneous leishmaniasis and enhancement of skin inflammation

S Naz, Z Ali, A Minhas, A Fatima, S Waseem - Microbial Pathogenesis, 2023 - Elsevier
Cutaneous Leishmaniasis (CL) affects millions of people globally and has a significant
impact on morbidity and mortality. Innate immune mediators are likely to influence the …

Sphingolipids protect ergosterol in the Leishmania major membrane from sterol-binding toxins

CS Haram, S Moitra, R Keane, FM Kuhlmann… - bioRxiv, 2022 - biorxiv.org
Nephrotoxicity is one common side effect of the first line anti-leishmanial treatment,
liposomal amphotericin B. Amphotericin B targets ergosterol, so one approach to reducing …