About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

The oocyte faces a particular challenge in terms of gene regulation. When oocytes resume
meiosis at the end of the growth phase and prior to ovulation, the condensed chromatin state …

The molecular causes of deteriorating oocyte quality during aging are poorly defined. Since
oocyte developmental competence relies on post-transcriptional regulations, we tested …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

STUDY QUESTION Can high resolution array-CGH analysis on a cohort of women showing
a primary ovarian insufficiency (POI) phenotype in young age identify copy number variants …

Objective To study the diagnostic yield, including variants in genes yet to be incriminated, of
whole exome sequencing (WES) in familial cases of premature ovarian insufficiency (POI) …

STUDY QUESTION Can a targeted whole exome sequencing (WES) on a cohort of women
showing a primary ovarian insufficiency (POI) phenotype at a young age, combined with a …

Primary ovarian insufficiency (POI), affecting up to 1 in 100 females, is characterized by
oligomenorrhea or amenorrhea with raised gonadotropins and low estradiol. It can result …

Objective To find the genetic etiology of premature ovarian insufficiency (POI) in a patient
with primary amenorrhea and hypergonadotropic hypogonadism. Design Case report …