Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …

Microneedles (MNs) have drawn rising attention owing to their merits of convenience,
noninvasiveness, flexible applicability, painless microchannels with boosted metabolism …

Obesity is a major public burden on the working population and induces chronic diseases.
Its treatment often requires long-term medication, which makes patient compliance difficult …

Obesity, a global public health concern, is an important risk factor for metabolic diseases
and several cancers. Fibro-inflammation in adipose tissues (ATs) is tightly associated with …

Adipose tissues are essential for actively regulating systemic energy balance, glucose
homeostasis, immune responses, reproduction, and longevity. Adipocytes maintain dynamic …

Carboxylesterase 1d (Ces1d) is a crucial enzyme with a wide range of activities in multiple
tissues. It has been reported to localize predominantly in ER. Here, we found that Ces1d …

Objectives Phloretin is ubiquitous in apples (Malus domestica) and other fruits and has
potential antidiabetic properties. Considering the preclinical potential of phloretin, its …

Adipose tissue is the site of long-term energy storage. During the fasting state, exercise, and
cold exposure, the white adipose tissue mobilizes energy for peripheral tissues through …