Essential core pathways of cellular biology are preserved throughout evolution, highlighting
the importance of these pathways for both bacteria and human cancer cells alike. Cell …

Multiple myeloma (MM) remains an incurable, genetically heterogeneous disease
characterized by the uncontrolled proliferation of transformed plasma cells nurtured within a …

Steroid hormone signaling is critical in the tumor progression and the regulation of
physiological mechanisms such as endoplasmic reticulum-associated degradation (ERAD) …

Thrombotic microangiopathy (TMA) has been reported to occur in multiple myeloma (MM)
patients in association with treatment with carfilzomib, an irreversible proteasome inhibitor …

MAIN TEXT Overcoming inherent and acquired drug resistance of MM cells, especially in the
context of the immunosuppressive tumor microenvironment (TME), remains a major …

Proteome aggregation is challenging to analyze given its loss of defined 3-D structures to
develop chemo-and bio-sensors. Herein, we present integrated chemical sensors to image …

In multiple myeloma (MM), while frequent mutations in driver genes are crucial for disease
progression, they traditionally offer limited insights into patient prognosis. This study aims to …

PURPOSE The gold standard for monitoring response status in patients with multiple
myeloma (MM) is serum and urine protein electrophoresis which quantify M-spike proteins; …

Multiple myeloma (MM) is the second most prevalent hematological malignancy and
remains incurable with remarkable heterogeneity in prognosis and treatment response …

Multiple myeloma grows by establishing multiple interactions with bone marrow cells. These
include expansion of myeloid-derived suppressor cells, which drive immunoevasion via …