Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …

Hepatic injury is associated with a defective intestinal barrier and increased hepatic
exposure to bacterial products. Here we report that the intestinal bacterial microflora and a …

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
superfamily, bind to two different serine/threonine kinase receptors, and mediate their …

The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate
biomarkers have hampered patient prognosis and treatment stratification. Recently, we have …

The Wnt pathway controls cell fate during embryonic development. It also persists as a key
regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational …

Wnt signaling plays an important role in embryonic development and tumorigenesis. These
biological effects are exerted by activation of the β-catenin/TCF transcription complex and …