Induction of homologous recombination by site-specific replication stress
MK Triplett, MJ Johnson, LS Symington - DNA repair, 2024 - Elsevier
ABSTRACT DNA replication stress is one of the primary causes of genome instability. In
response to replication stress, cells can employ replication restart mechanisms that rely on …
response to replication stress, cells can employ replication restart mechanisms that rely on …
The fission yeast SUMO-targeted ubiquitin ligase Slx8 functionally associates with clustered centromeres and the silent mating-type region at the nuclear periphery
S Chakraborty, J Strachan, K Schirmeisen… - Biology …, 2024 - journals.biologists.com
The SUMO-targeted ubiquitin ligase (STUbL) family is involved in multiple cellular
processes via a wide range of mechanisms to maintain genome stability. One of the …
processes via a wide range of mechanisms to maintain genome stability. One of the …
[PDF][PDF] A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin …
AA Saada, T van Emden, M Capella… - Nucleic Acids …, 2024 - researchgate.net
Heterochromatin plays a critical role in regulating gene expression and maintaining genome
integrity. While structural and enzymatic components have been linked to heterochromatin …
integrity. While structural and enzymatic components have been linked to heterochromatin …
Multifaceted roles of SUMO in DNA metabolism
YM Thu - Nucleus, 2024 - Taylor & Francis
Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target
proteins, emerges as a post-translational modification that mediates protein− protein …
proteins, emerges as a post-translational modification that mediates protein− protein …
[HTML][HTML] Ulp1 Regulates Cell Proliferation Through INO1 in Pichia pastoris
J Yang, B Zhong, L Yang, Z Luo, L Jia, K Zheng… - Genes, 2024 - mdpi.com
Background/Objectives: Ulp1 is a vital regulator of the cell cycle, with its absence leading to
G2/M phase arrest in Saccharomyces cerevisiae. This study aims to investigate the role of …
G2/M phase arrest in Saccharomyces cerevisiae. This study aims to investigate the role of …
Rap1-dependent replication stress at telomeres induces relocalization to the Nuclear Pore Complexes
M Al Hajj, M Pierre, M Dubarry, M Chang, V Géli… - 2024 - hal.science
Nuclear pore complexes (NPCs) have emerged as a key structure in the spatial regulation of
DNA damage repair, including at replication forks that are slowed down or stalled at various …
DNA damage repair, including at replication forks that are slowed down or stalled at various …
Multifaceted role of SUMOylation in maintaining centromere biology and regulation of replication fork restart in Schizosaccharomyces pombe
S Chakraborty - 2024 - theses.hal.science
Flaws in the DNA replication process, known as replication stress, is a major source of
genome instability that fuels cancer development. Resolution of replication stress occurs …
genome instability that fuels cancer development. Resolution of replication stress occurs …
Investigating the Impact of Site-Specific Replication Stress on Homologous Recombination
MK Triplett - 2024 - search.proquest.com
Genomic instability is a hallmark of cancer that can be caused by various forms of DNA
replication stress. Collision of the replication fork with obstacles ahead of the replication …
replication stress. Collision of the replication fork with obstacles ahead of the replication …