Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatment
E Antonucci, E Fiaccadori, K Donadello, FS Taccone… - Journal of critical …, 2014 - Elsevier
The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a
common finding associated with increased morbidity and mortality. Myocardial depression …
common finding associated with increased morbidity and mortality. Myocardial depression …
Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies
Objective: Catecholaminergic inotropes have a place in the management of low output
syndrome and decompensated heart failure but their effect on mortality is debated …
syndrome and decompensated heart failure but their effect on mortality is debated …
Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure
Global epidemiological studies reported a shift from maternal/infectious communicable
diseases to chronic non-communicable diseases and a major part is attributable to …
diseases to chronic non-communicable diseases and a major part is attributable to …
Evidence-based use of levosimendan in different clinical settings
L De Luca, WS Colucci, MS Nieminen… - European heart …, 2006 - academic.oup.com
Levosimendan is a new calcium sensitizer and K-ATP channel opener. Compared with other
inodilators, it improves myocardial contractility without increasing oxygen requirements and …
inodilators, it improves myocardial contractility without increasing oxygen requirements and …
Levosimendan is superior to enoximone in refractory cardiogenic shock complicating acute myocardial infarction
JT Fuhrmann, A Schmeisser, MR Schulze… - Critical care …, 2008 - journals.lww.com
Objective: Cardiogenic shock is the leading cause of death in patients hospitalized for acute
myocardial infarction. The objectives were to investigate the effects of levosimendan, a novel …
myocardial infarction. The objectives were to investigate the effects of levosimendan, a novel …
[HTML][HTML] Preoperative levosimendan decreases mortality and the development of low cardiac output in high-risk patients with severe left ventricular dysfunction …
R Levin, M Degrange, C Del Mazo… - … & Clinical Cardiology, 2012 - ncbi.nlm.nih.gov
BACKGROUND: The calcium sensitizer levosimendan has been used in cardiac surgery for
the treatment of postoperative low cardiac output syndrome (LCOS) and difficult weaning …
the treatment of postoperative low cardiac output syndrome (LCOS) and difficult weaning …
Clinical pharmacology of levosimendan
S Antila, S Sundberg, LA Lehtonen - Clinical pharmacokinetics, 2007 - Springer
Levosimendan has been developed for the treatment of decompensated heart failure and is
used intravenously when patients with heart failure require immediate initiation of drug …
used intravenously when patients with heart failure require immediate initiation of drug …
Identification of inflammatory mediators and their modulation by strategies for the management of the systemic inflammatory response during cardiac surgery
R Hall - Journal of Cardiothoracic and Vascular Anesthesia, 2013 - jcvaonline.com
THE SYSTEMIC INFLAMMATORY RESPONSE (man-ifested by pyrexia, leukocytosis,
tachycardia, hypotension, tissue fluid accumulation, and organ failure) is generated during …
tachycardia, hypotension, tissue fluid accumulation, and organ failure) is generated during …
Cytokines and acute heart failure
D Chen, C Assad-Kottner, C Orrego… - Critical care …, 2008 - journals.lww.com
In patients with chronic heart failure, ongoing myocardial injury partially results from
activation of the inflammatory system, with production and release of proinflammatory …
activation of the inflammatory system, with production and release of proinflammatory …
Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome
K Uhlig, L Efremov, J Tongers, S Frantz… - Cochrane Database …, 2020 - cochranelibrary.com
Background Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) are
potentially life‐threatening complications of acute myocardial infarction (AMI), heart failure …
potentially life‐threatening complications of acute myocardial infarction (AMI), heart failure …