Background Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or
metastatic oropharyngeal head and neck squamous cell carcinoma in the first-and second …

Premetastatic cancer cells often spread from the primary lesion through the lymphatic
vasculature and, clinically, the presence or absence of lymph node metastases impacts …

Steroid hormones are derived from cholesterol and can be classified into sex hormones
(estrogens, androgens, progesterone) that are primarily synthesized in the gonads and …

Tumor immunology has been studied extensively. Tumor immunology–based cancer
immunotherapy has become one of the most promising approaches for cancer treatment …

Sex differences in cancer risk and outcome are currently a topic of major interest in clinical
oncology. It is however unknown to what extent cancer researchers consider sex as a …

The second messenger cyclic guanosine monophosphate (cGMP) is an important regulator
of human (patho-) physiology and has emerged as an attractive drug target. Currently, cGMP …

Immunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+
T cells, but have a limited patient response rate, in part due to limited tumoral immune cell …

Sustained release of vaccine components is a potential method to boost efficacy compared
with traditional bolus injection. Here, we show that a biodegradable hyaluronic acid (HA) …

Simple Summary Pancreatic ductal adenocarcinoma continues to be one of the deadliest
cancers worldwide. Preclinical studies involving animals rarely include sex as a major …

Cancer diseases lead to the second-highest death rate all over the world. For treating
tumors, one of the most common schemes is chemotherapy, which can decrease the tumor …