Purpose The purpose of this study was to determine the normal physiologic timing of the
closure of the metopic suture in non-craniosynostotic patients. Methods This clinical study …

Neural crest cells appear early during embryogenesis and give rise to many structures in the
mature adult. In particular, a specific population of neural crest cells migrates to and …

A study of skull thickness and resistivity variations over the upper surface was made for an
adult human skull. Physical measurements of thickness and qualitative analysis of …

Only the metopic suture normally fuses during early childhood; all other cranial sutures
normally fuse much later in life. Despite this, metopic synostosis is one of the least common …

Craniofacial abnormalities often involve sutures, the growth centers of the skull. To
characterize the organization and processes governing their development, we profile the …

The cranial bones constitute the protective structures of the skull, which surround and protect
the brain. Due to the limited repair capacity, the reconstruction and regeneration of skull …

Craniosynostosis, a developmental disorder resulting from premature closure of the gaps
(sutures) between skull bones, can be caused by excessive intramembranous ossification, a …

The term craniosynostosis was first used in 1830 by Otto to describe the premature fusion of
cranial sutures (Otto, 1830). Since this first identification of craniosynostosis as a distinct …

Sutures are fibrous joints in the vertebrate skull. They consist of two bone ends and
intervening fibrous tissue which differentiates from embryonic mesenchyme. Sutures are not …

Cranial suture development involves a complex interaction of genes and tissues derived
from neural crest cells (NCC) and paraxial mesoderm. In mice, the posterior frontal (PF) …