Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

Adult CNS neurons are typically described as permanently postmitotic but there is probably
nothing permanent about the neuronal cell cycle arrest. Rather, it appears that these highly …

The E2F transcription factors are critical regulators of genes required for appropriate
progression through the cell cycle, and in special circumstances they can also promote the …

Inactivation of the retinoblastoma (RB1) tumor suppressor is one of the most frequent and
early recognized molecular hallmarks of cancer. RB1, although mainly studied for its role in …

After completion of this article, the reader will be able to 1) state the therapeutic interventions
that are currently used to treat intraocular retinoblastoma, and to outline the mechanism of …

Recent studies suggest that postmitotic neurons can reenter the cell cycle as a prelude to
apoptosis after brain injury. However, most dying neurons do not pass the G1/S-phase …

The retinoblastoma protein (pRB) is a critical regulator of cell proliferation and differentiation
and an important tumor suppressor. In the G1 phase of the cell cycle, pRB localizes to …

Summary pRB can enforce a G1 block by repressing E2F-responsive promoters. It also
coactivates certain non-E2F transcription factors and promotes differentiation. Some pRB …

Embryonic chimeras of the mouse are well-established tools for studying cell lineage and
cell potential. They are also a key part of the analysis of complex phenotypes of mutant mice …

Summary The Rb family, Rb, p107, and p130, play important roles in cell cycle control and
cellular differentiation, and Rb has been suggested to regulate adipocyte differentiation. We …