The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Hyaluronic acid (HA), the main component of extracellular matrix, is considered one of the
key players in the tissue regeneration process. It has been proven to modulate via specific …

Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular
matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans …

In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early
stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 …

Angiogenesis is crucial for the success of most tissue engineering strategies. The natural
inflammatory response is a major regulator of vascularization, through the activity of different …

Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid
and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the …

Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

Wound healing involves a series of carefully modulated steps, from initial injury and blood
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …

The cell-surface glycoprotein CD44 is involved in a multitude of important physiological
functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte …