Regulation of VEGFR signalling in lymphatic vascular development and disease: an update

GA Secker, NL Harvey - International journal of molecular sciences, 2021 - mdpi.com
The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining
recognition; lymphatic vessel dysfunction is a feature of disorders including congenital …

Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

B Wu, W Xu, K Wu, Y Li, M Hu, C Feng, C Zhu… - Nature Ecology & …, 2024 - nature.com
The evolution of the vertebrate liver is a prime example of the evolution of complex organs,
yet the driving genetic factors behind it remain unknown. Here we study the evolutionary …

Proteolytic cleavages in the VEGF family: generating diversity among angiogenic VEGFs, essential for the activation of lymphangiogenic VEGFs

J Künnapuu, H Bokharaie, M Jeltsch - Biology, 2021 - mdpi.com
Simple Summary Vascular endothelial growth factors (VEGFs) regulate the growth of blood
and lymphatic vessels. Some of them induce the growth of blood vessels, and others the …

Mechanisms and cell lineages in lymphatic vascular development

DJ Jafree, DA Long, PJ Scambler, C Ruhrberg - Angiogenesis, 2021 - Springer
Lymphatic vessels have critical roles in both health and disease and their study is a rapidly
evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in …

Endothelial cell dynamics in vascular development: insights from live-imaging in zebrafish

KS Okuda, BM Hogan - Frontiers in Physiology, 2020 - frontiersin.org
The formation of the vertebrate vasculature involves the acquisition of endothelial cell
identities, sprouting, migration, remodeling and maturation of functional vessel networks. To …

The relationship between the secondary vascular system and the lymphatic vascular system in fish

V Panara, Z Varaliová, J Wilting, K Koltowska… - Biological …, 2024 - Wiley Online Library
New technologies have resulted in a better understanding of blood and lymphatic vascular
heterogeneity at the cellular and molecular levels. However, we still need to learn more …

Oxamyl exerts developmental toxic effects in zebrafish by disrupting the mitochondrial electron transport chain and modulating PI3K/Akt and p38 Mapk signaling

G An, T Hong, H Park, W Lim, G Song - Science of The Total Environment, 2023 - Elsevier
Oxamyl, a carbamate insecticide, is mainly used to control nematodes in the agricultural
field. Although oxamyl is a widely used insecticide that is associated with ecological …

Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis

AR Fetsko, DJ Sebo, MR Taylor - Developmental biology, 2023 - Elsevier
During neurovascular development, brain endothelial cells (BECs) respond to secreted
signals from the neuroectoderm that regulate CNS angiogenesis, the formation of new blood …

Angiotensin II stimulates the proliferation and migration of lymphatic endothelial cells through angiotensin type 1 receptors

QY Lin, J Bai, JQ Liu, HH Li - Frontiers in Physiology, 2020 - frontiersin.org
Background/Aim The proliferation and migration of lymphatic endothelial cells (LECs) is
essential for lymphatic vessel growth (also known as lymphangiogenesis), which plays a …