Positron emission tomography (PET) provides dynamic images of the biodistribution of
radioactive tracers in the brain. Through application of the principles of compartmental …

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain,
particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after …

Traumatic brain injury is the number one cause of death and disability among the pediatric
population in the USA. The heterogeneity of the pediatric population is reflected by both the …

Activation of the mammalian target of rapamycin (mTOR) leads to cell growth and survival.
We tested the hypothesis that inhibition of mTOR would increase infarct size and decrease …

At present, the goal of stroke research is the identification of a potential recoverable tissue
surrounding the ischemic core, suggested as ischemic penumbra, with the aim of applying a …

The facilitative glucose transport protein GLUT1 has important roles in positron emission
tomography (PET) imaging of human diseases. GLUT1 has widespread expression and …

There have been reports that activation of Akt may provide neuroprotection after cerebral
ischemia-reperfusion. We tested the hypothesis that activation of Akt would decrease infarct …

Background and Purpose—Experimental stroke models are essential to study in vivo
pathophysiological processes of focal cerebral ischemia. In this study, an embolic stroke …

Prenatal and early postnatal periods are important for brain development and neural
function. Neonatal insults such as hypoxia‐ischemia (HI) causes prolonged neural and …

Purpose This study evaluates the performance of simultaneous dual-tracer technique
(SDTT) in static positron emission tomography (PET) studies using 2-deoxy-2-[18 F] fluoro-D …