Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Tryptophan, the most chemically complex and the least abundant of the 20 common
proteinogenic amino acids, is a biosynthetic precursor to a large number of complex …

Diverse β-carboline (βC) alkaloids are produced by microbes, plants, and animals with
myriad bioactivities and drug potentials. However, the biosynthetic mechanism of βCs …

Amide bond-containing (ABC) biomolecules are some of the most intriguing and functionally
significant natural products with unmatched utility in medicine, agriculture and …

This review covers the development of the genus Micromonospora as a model for natural
product research and the timeline of discovery progress from the classical bioassay-guided …

Streptonigrin is an aminoquinone alkaloid isolated from Streptomyces flocculus and is
gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It …

The total synthesis of (±)-streptonigrin, a potent tetracyclic aminoquinoline-5, 8-dione
antitumor antibiotic that reached phase II clinical trials in the 1970s, is described. Two routes …

Oxygen‐directed methylation is a ubiquitous tailoring reaction in natural product pathways
catalysed by O‐methyltransferases (OMTs). Promiscuous OMT biocatalysts are thus a …

Nicotinamide adenine dinucleotide (NAD+) is a life essential molecule involved in versatile
biological processes. To date, only two de novo biosynthetic routes to NAD+ are described …

Streptomycetes represent an important reservoir of active secondary metabolites with
potential applications in the pharmaceutical industry. The gene clusters responsible for their …