As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a
significant protease which plays vital roles in many biological processes. MMP-9 can cleave …

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …

Transcriptional regulation is often the convergence point of oncogenic signaling. It is not
surprising, therefore, that aberrant gene expression is a hallmark of cancer. Transformed …

Despite extensive efforts to target mutated RAS proteins, anticancer agents capable of
selectively killing tumour cells harbouring KRAS mutations have remained unavailable …

Taiwan, ROC. Received February 25, 2010; accepted July 1, 2010; published online July
23, 2010 a-Solanine, a naturally occurring steroidal glycoalkaloid in potato sprouts, was …

In the natural cellular environment, nucleic acid biomolecules like DNA have biological
implications via structural modifications and through precise coordination with other …

Recent innovations in cutting-edge sequencing platforms have allowed the rapid
identification of genes associated with communicable, noncommunicable and rare diseases …

Androgen receptor (AR) functions as a ligand-dependent transcription factor to regulate its
downstream signaling for prostate cancer progression. AR complex formation by multiple …

Background: Protease serine 8 (PRSS8), a trypsin-like serine peptidase, has been shown to
function as a tumour suppressor in various malignancies. The present study aimed to …

Polymeric prodrugs are of immense interest as anticancer drug-delivery system owing to
their superior drug stability during circulation and satisfactory drug loading capacity …