The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

Recent studies suggest that neuropilin-1 (NRP-1) promotes angiogenesis mainly via VEGF
and its receptors. It promotes tumorigenesis via formation of the NRP-1/VEGF (vascular …

The high mortality of epithelial ovarian cancer (EOC) is mainly caused by resistance to the
available therapies. In EOC, the endothelin-1 (ET-1, EDN1)–endothelin A receptor (ETAR …

Background Previous reports showed that the Steroidal Glycoalkaloid Solamargine inhibited
proliferation of non-melanoma skin cancer cells. However, Solamargine was not tested …

Angiogenesis is a process that forms new blood capillaries from existing vessels, which is of
great physiological and pathological significance. Although recent studies provide evidence …

Diosgenin is a natural steroidal saponin that is extracted from a range of sources, including
from fenugreek. It is a critical raw material in the synthesis of steroid hormone drugs …

Background Multilevel data integration is becoming a major area of research in systems
biology. Within this area, multi-'omics datasets on complex diseases are becoming more …

Over the past few decades, the development of broad-spectrum anticancer agents with anti-
angiogenic activity has witnessed considerable progress. In this study, a new series of …

Significance: The uses of anti-angiogenic drugs have not only made an impact on the battle
to eliminate cancer but are also responsible for a number of medical complications. The long …

A robust immunohistochemical (IHC) assay for VEGFR2 was developed to investigate its
utility for patient tailoring in clinical trials. The sensitivity, specificity, and selectivity of the IHC …