The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

During the last few years, the endocannabinoid system has emerged as a highly relevant
topic in the scientific community. Many different regulatory actions have been attributed to …

Pharmacological Actions of Cannabinoids | SpringerLink Skip to main content Advertisement
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …

In the case of the cannabinoid receptor, the lack of potent antagonists has been a limiting
factor in defining cannabinoid receptor-mediated responses. Several lines of evidence …

Δ9-Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs
such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528 …

The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

▪ Abstract CB1 and CB2 cannabinoid receptors are the primary targets of endogenous
cannabinoids (endocannabinoids). These G protein–coupled receptors play an important …

N-arachidonoylethanolamine (anandamide) was the first endogenous cannabinoid receptor
ligand to be discovered. Dual synthetic pathways for anandamide have been proposed. One …

Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1
cannabinoid receptor. However, little is known about what happens to the receptor as …