Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons

K He, Y Han, X Li, RX Hernandez… - Journal of …, 2023 - Soc Neuroscience
Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the
circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity …

To Ib or not to b: Transcriptional regulation of tonic type Ib vs. phasic type Is motor neurons

AT Medeiros, K O'Connor-Giles - Neuron, 2023 - cell.com
Neuronal diversity is a hallmark of the nervous system that has captivated scientists for over
a century. In this issue of Neuron, Suresh Jetti and colleagues report the identification of …

Muscle-fiber specific genetic manipulation of Drosophila sallimus severely impacts neuromuscular development, morphology, and physiology

AH Michael, TA Hana, VG Mousa… - Frontiers in Physiology, 2024 - frontiersin.org
The ability of skeletal muscles to contract is derived from the unique genes and proteins
expressed within muscles, most notably myofilaments and elastic proteins. Here we …

A stochastic RNA editing process targets a limited number of sites in individual Drosophila glutamatergic motoneurons

AB Crane, SK Jetti, JT Littleton - bioRxiv, 2024 - biorxiv.org
RNA editing is a post-transcriptional source of protein diversity and occurs across the animal
kingdom. Given the complete profile of mRNA targets and their editing rate in individual cells …