Temozolomide–hesperetin drug–drug cocrystal with optimized performance in stability, dissolution, and tabletability

J Wang, XL Dai, TB Lu, JM Chen - Crystal Growth & Design, 2021 - ACS Publications
A new 1: 1 drug–drug cocrystal of temozolomide and hesperetin was successfully prepared
by liquid-assisted grinding, slurry conversion crystallization, and evaporation crystallization …

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

H Yu, L Zhang, M Liu, D Yang, G He, B Zhang, N Gong… - Pharmaceuticals, 2023 - mdpi.com
To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five
novel solid forms in 1: 1 stoichiometry were obtained upon liquid-assisted grinding, slurry …

Physicochemical and mechanical properties of paracetamol cocrystal with 5-nitroisophthalic acid

S Hiendrawan, B Veriansyah, E Widjojokusumo… - International journal of …, 2016 - Elsevier
We report novel pharmaceutical cocrystal of a popular antipyretic drug paracetamol (PCA)
with coformer 5-nitroisophhthalic acid (5NIP) to improve its tabletability. The cocrystal (PCA …

Advanced methodologies for pharmaceutical salt synthesis

MS Hossain Mithu, S Economidou, V Trivedi… - Crystal Growth & …, 2021 - ACS Publications
Pharmaceutical salt formation is the most preferred and effective method to enhance the
physicochemical properties of an active pharmaceutical ingredient (API) such as solubility …

Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin

JH Deng, TB Lu, CC Sun, JM Chen - European Journal of Pharmaceutical …, 2017 - Elsevier
Dapagliflozin (DAP) is a potent and selective sodium-glucose contransporter-2 inhibitor, for
treating type 2 diabetes. DAP propanediol monohydrate (DAP-PDO-H 2 O, 1: 1: 1) is the …

Solubility and permeability improvement of allopurinol by cocrystallization

XL Dai, J Yao, C Wu, JH Deng, YH Mo… - Crystal Growth & …, 2020 - ACS Publications
Allopurinol is a xanthine oxidase inhibitor with poor solubility and permeability, which
severely limit its drug absorption following the administration of some dosage forms, such as …

Ketoconazole-p-aminobenzoic Acid Cocrystal: Revival of an Old Drug by Crystal Engineering

F Martin, M Pop, I Kacso, IG Grosu… - Molecular …, 2020 - ACS Publications
The 1: 1 cocrystal of the antifungal agent ketoconazole with p-aminobenzoic acid was
successfully crystallized and systematically characterized by a physical and …

Enhanced anticancer activities of curcumin-loaded green gum acacia-based silver nanoparticles against melanoma and breast cancer cells

I Ali, SBM Ahmed, BM Elhaj, HS Ali, A Alsubaie… - Applied …, 2021 - Springer
Nano-anticancer drugs are gaining importance in cancer treatment due to their unique
properties and wide range of applications. The efforts are made to synthesize silver …

Processing of ketoconazole–4-aminobenzoic acid cocrystals using dense CO2 as an antisolvent

G Kotbantao, M Charoenchaitrakool - Journal of CO2 Utilization, 2017 - Elsevier
The aim of this work was to improve the dissolution rate of a poorly water–soluble antifungal
drug, ketoconazole (KET), by forming cocrystal with 4-amino benzoic acid (PABA). Gas Anti …

Pharmaceutical salts of carvedilol: polymorphism and physicochemical properties

S Hiendrawan, E Widjojokusumo, B Veriansyah… - Aaps Pharmscitech, 2017 - Springer
We report novel pharmaceutical salts of an anti-hypertensive drug carvedilol (CVD) with
pharmaceutically acceptable salt formers, including oxalic acid (OXA), fumaric acid (FUMA) …