Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

ABSTRACT Introduction: Telomere biology disorders (TBDs) encompass a group of
illnesses caused by germline mutations in genes regulating telomere maintenance, resulting …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

The p53 protein has been extensively studied for its capacity to prevent proliferation of cells
with a damaged genome. Surprisingly, however, our recent analysis of mice expressing a …

RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and
decay. Guanylation of the poly (A) tail was discovered recently, yet the enzymology and …

Genetic lesions that reduce telomerase activity inhibit stem cell replication and cause a
range of incurable diseases, including dyskeratosis congenita (DC) and pulmonary fibrosis …

Active telomerase is essential for stem cells and most cancers to maintain telomeres. The
enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the …

Telomere biology disorders (TBD) are a heterogeneous group of diseases arising from
germline mutations affecting genes involved in telomere maintenance. Telomeres are DNA …