The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

Conspectus 3, 3-Disubstituted oxindoles are widely distributed in natural products, drugs,
and pharmaceutically active compounds. The absolute configuration and the substituents on …

1. INTRODUCTION Despite being largely absent from natural products and biological
processes, fluorine plays a conspicuous and increasingly important role within …

Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …

Direct difunctionalization of simple alkenes, the incorporation of two functional groups onto a
carbon–carbon double bond, is of particular interest to the chemical community owing to its …

Electrophilic trifluoromethylation reactions have been the latest approach to achieve the
fluoroalkylation of compounds with newly‐discovered reagents, such as the Togni's (1 …

Charming fluorine: This Essay examines the recent surge in late-stage fluorination reactions
and outlines challenges that need to be overcome to increase the impact of modern …

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis.
Recent years have witnessed increasing interest towards the use of highly active and …