The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

Super-resolution microscopy techniques, and specifically single-molecule localization
microscopy (SMLM), are approaching nanometer resolution inside cells and thus have great …

Meiotic crossovers (COs) have intriguing patterning properties, including CO interference,
the tendency of COs to be well-spaced along chromosomes, and heterochiasmy, the marked …

The synaptonemal complex is a tripartite proteinaceous ultrastructure that forms between
homologous chromosomes during prophase I of meiosis in the majority of eukaryotes. It is …

The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

Super-resolution microscopy, and specifically single-molecule localization microscopy
(SMLM), is becoming a transformative technology for cell biology, as it allows the study of …

The formation of crossovers between homologous chromosomes is key to sexual
reproduction. In most species, crossovers are spaced further apart than would be expected if …

Meiotic crossovers, which are exchanges of genetic material between homologous
chromosomes, are more evenly and distantly spaced along chromosomes than expected by …

Multi-channel detection in single-molecule localization microscopy greatly increases
information content for various biological applications. Here, we present globLoc, a graphics …

The successful delivery of genetic material to gametes requires tightly regulated interactions
between the parental chromosomes. Central to this regulation is a conserved chromosomal …