Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Amongst the various microtubule-targeting agents, Docetaxel (DTX) has gained immense
attention in cancer chemotherapy due to its good therapeutic index. DTX belongs to the …

Photodynamic therapy (PDT) shows a promising synergy with chemotherapy in the
therapeutic outcome of malignant cancers. The minimal invasiveness and nonsystemic …

Most cancer disease can be treated by the parenteral anticancer delivery method. The
intravenous route takes the wholly bioavailable, accurate dose of the drug immediately to …

Oral delivery is the most accepted and economical route for drug administration and leads to
substantial reduction in dosing frequency. However, this route still remains a challenge for …

Unsaturated fatty acids (UFAs), with the distinct advantages of good biocompatibility and
innate tumor-targeting effect, have been widely investigated for the rational design of …

The oral delivery of cancer chemotherapeutic drugs is challenging due to low bioavailability,
gastrointestinal side effects, first-pass metabolism and P-glycoprotein efflux pumps. Thus …

Many drug molecules that are currently in the market suffer from short half-life, poor
absorption, low specificity, rapid degradation, and resistance development. The design and …

The natural product berberine (BBR), present in various plants, arouses great interests
because of its numerous pharmacological effects. However, the further development and …

The therapeutic efficacy of orally administered drugs is often restricted by their inherent
limited oral bioavailability. Low water solubility, limited permeability through the intestinal …