Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms

A Yiangou, SP Mollan, AJ Sinclair - Nature Reviews Neurology, 2023 - nature.com
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few
years. Previously, IIH was considered a disease exclusively affecting the neuro-ophthalmic …

Headache attributed to idiopathic intracranial hypertension and persistent Post‐Idiopathic intracranial hypertension headache: a narrative review

SP Mollan, O Grech, AJ Sinclair - … The Journal of Head and Face …, 2021 - Wiley Online Library
Objective Headache is a near‐universal sequela of idiopathic intracranial hypertension (IIH).
The aim of this paper is to report current knowledge of headache in IIH and to identify …

[HTML][HTML] Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension

CSJ Westgate, HF Botfield, Z Alimajstorovic… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND Idiopathic intracranial hypertension (IIH) is a condition predominantly
affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease …

Association between idiopathic intracranial hypertension and risk of cardiovascular diseases in women in the United Kingdom

NJ Adderley, A Subramanian… - JAMA …, 2019 - jamanetwork.com
Importance Cardiovascular disease (CVD) risk has not been previously evaluated in a large
matched cohort study in idiopathic intracranial hypertension (IIH). Objectives To estimate the …

Association of amount of weight lost after bariatric surgery with intracranial pressure in women with idiopathic intracranial hypertension

SP Mollan, JL Mitchell, A Yiangou, RS Ottridge… - Neurology, 2022 - AAN Enterprises
Background and Objectives The idiopathic intracranial hypertension randomized controlled
weight trial (IIH: WT) established that weight loss through bariatric surgery significantly …

Metabolic concepts in idiopathic intracranial hypertension and their potential for therapeutic intervention

C Hornby, SP Mollan, H Botfield… - Journal of Neuro …, 2018 - journals.lww.com
Background: Traditional risk factors associated with idiopathic intracranial hypertension (IIH)
include obesity, weight gain, and female sex. The incidence of IIH is increasing and yet the …

11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in idiopathic intracranial hypertension

RS Hardy, H Botfield, K Markey… - The Journal of …, 2021 - academic.oup.com
Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
determines prereceptor metabolism and activation of glucocorticoids within peripheral …

Incidence, prevalence, and health care outcomes in idiopathic intracranial hypertension: a population study

L Miah, H Strafford, B Fonferko-Shadrach… - Neurology, 2021 - AAN Enterprises
Objective To characterize trends in incidence, prevalence, and health care outcomes in the
idiopathic intracranial hypertension (IIH) population in Wales using routinely collected health …

The potentially modifiable risk factor in idiopathic intracranial hypertension: body weight

SP Mollan, AA Tahrani, AJ Sinclair - Neurology: Clinical Practice, 2021 - AAN Enterprises
Purpose of Review Idiopathic intracranial hypertension (IIH) prevalence increased in
conjunction with rising obesity rates. Here, we highlight the importance of weight …

Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset

M Thaller, J Mytton, BR Wakerley… - … Journal of Obstetrics …, 2022 - Wiley Online Library
Objective Idiopathic intracranial hypertension (IIH) predominantly affects women of
reproductive age with obesity, and these women have a distinct profile of hyperandrogenism …