Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes,
playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular …

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …

The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Fluorene is a commonly identified PAH pollutant in soil and exhibits various worrisome
hazardous effects to soil organisms. Currently, the toxicity profiles of fluorene on earthworm …

Emerging evidence indicates that l-glutamine (Gln) plays a fundamental role in
cardiovascular physiology and pathology. By serving as a substrate for the synthesis of …

The blood–brain barrier is a highly selective anatomical and functional interface allowing a
unique environment for neuro-glia networks. Blood–brain barrier dysfunction is common in …

Heme oxygenase-1, an enzyme degrading heme to carbon monoxide, iron, and biliverdin,
has been recognized as playing a crucial role in cellular defense against stressful …

As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO)
has been neglected for many years, and only recently has its role as an essential signaling …

Carbon monoxide (CO) is produced by heme oxygenase (HO)-catalyzed heme degradation
to CO, iron, and biliverdin. HO has two active isoforms, HO-1 (inducible) and HO-2 …