Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

Macrophages are critically involved in wound healing, from dampening inflammation to
clearing cell debris and coordinating tissue repair. Within the wound, the complexity of …

Biomaterial implantation is followed by an inflammatory cascade dominated by
macrophages, which determine implant acceptance or rejection through pro-and anti …

Scarring is part of the normal healing response to tissue injury in all organs and required to
rapidly repair acute damages, mostly with extracellular matrix. A variety of different cells are …

Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue
microenvironment. Although much is known about how soluble factors influence …

Macrophage (Mϕ)-fibroblast interactions coordinate tissue repair after injury whereas
miscommunications can result in pathological healing and fibrosis. We show that contracting …

Macrophages are tissue-resident immune cells that play a critical role in maintaining
homeostasis and fighting infection. In addition, these cells are involved in the progression of …

Macrophages respond to chemical/metabolic and physical stimuli, but their effects cannot be
readily decoupled in vivo during pro-inflammatory activation. Here, we show that preventing …