Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …

Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma

G Geidel, I Heidrich, J Kött, SW Schneider… - NPJ Precision …, 2022 - nature.com
Advanced cutaneous squamous cell carcinoma (cSCC) encompasses unresectable and
metastatic disease. Although immune checkpoint inhibition has been approved for this entity …

Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer

M Bayoumi, MG Arafa, M Nasr, OA Sammour - Scientific Reports, 2021 - nature.com
Skin cancer is one of the most dangerous diseases, leading to massive losses and high
death rates worldwide. Topical delivery of nutraceuticals is considered a suitable approach …

Deciphering the molecular landscape of cutaneous squamous cell carcinoma for better diagnosis and treatment

AD Lazar, S Dinescu, M Costache - Journal of Clinical Medicine, 2020 - mdpi.com
Cutaneous squamous cell carcinoma (cSCC) is a common type of neoplasia, representing a
terrible burden on patients' life and clinical management. Although it seldom metastasizes …

[HTML][HTML] The Mutational and Microenvironmental Landscape of Cutaneous Squamous Cell Carcinoma: A Review

TM Hosseini, SJ Park, T Guo - Cancers, 2024 - mdpi.com
Simple Summary Cutaneous squamous cell carcinoma (cSCC) is a complex disease arising
from an interplay of UV-induced DNA damage, genetic mutations, and alterations in the …

From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention

M Mitsiogianni, T Amery, R Franco… - Pharmacology & …, 2018 - Elsevier
Skin cancer incidence is rapidly growing over the last decades and is generally divided into
malignant melanoma and non-melanoma (NMSC) with the latter being subdivided into …

Itraconazole inhibits the growth of cutaneous squamous cell carcinoma by targeting HMGCS1/ACSL4 axis

C Xu, Y Zhuo, Y Liu, H Chen - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous cancer
with increasing incidence. Itraconazole has been identified as a potential anticancer drug …

[HTML][HTML] Role of non-coding RNAs in the progression and resistance of cutaneous malignancies and autoimmune diseases

AQ Khan, F Ahmad, SS Raza, L Zarif, KS Siveen… - Seminars in cancer …, 2022 - Elsevier
Skin, the largest organ of human body, is vital for the existence and survival of human
beings. Further, developmental and physiological mechanisms associated with cutaneous …

[HTML][HTML] Micro RNA Dysregulation in Keratinocyte Carcinomas: Clinical Evidence, Functional Impact, and Future Directions

J Conley, B Genenger, B Ashford… - International Journal of …, 2024 - mdpi.com
The keratinocyte carcinomas, basal cell carcinoma (BCC), and cutaneous squamous cell
carcinoma (cSCC), are the most common cancers in humans. Recently, an increasing body …

MicroRNA-125b exerts antitumor functions in cutaneous squamous cell carcinoma by targeting the STAT3 pathway

K Tian, W Liu, J Zhang, X Fan, J Liu, N Zhao… - Cellular & molecular …, 2020 - Springer
Abstract Background MicroRNA-125b (miR-125b) is downregulated in human cutaneous
squamous cell carcinoma (CSCC). However, its function in CSCC has yet to be extensively …