Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

The WT1 (Wilms' tumour 1) gene encodes a zinc finger transcription factor and RNA-binding
protein that direct the development of several organs and tissues. WT1 manifests both …

Life experience can leave lasting marks, such as epigenetic changes, in the brain. How life
experience is translated into storable epigenetic information remains largely unknown. With …

Store-operated calcium entry (SOCE) regulates a wide variety of essential cellular functions.
SOCE is mediated by STIM1 and STIM2, which sense depletion of ER Ca2+ stores and …

In mammalian DNA, cytosine occurs in several chemical forms, including unmodified
cytosine (C), 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine …

Background Endothelial progenitor cells (EPCs) may be recruited from bone marrow to
sustain tumor vascularisation and promote the metastatic switch. Understanding the …

DNA methylation is a prevalent epigenetic modification involved in regulating a number of
essential cellular processes, including genomic accessibility and transcriptional outcomes …

T‐cell activation involves a complex signalling cascade uniquely dependent on elevated
cytosolic Ca2+ levels. Further, the spatiotemporal characteristics of this Ca2+ signal play a …

Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of alpha
and beta herpesvirus latency. We have previously shown that the beta-herpesvirus, human …

Intracellular free Ca 2+ ions regulate many cellular functions, and in turn, the cell devotes
many genes/proteins to keep tight control of the level of intracellular free Ca 2+. Here, we …