The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates
all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a …

As obligate intracellular parasites, viruses are dependent on their infected hosts for survival.
Consequently, viruses are under enormous selective pressure to utilize available cellular …

Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform
for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors …

African swine fever virus (ASFV) represents a severe threat to global agriculture with the
world's domestic pig population reduced by a quarter following recent outbreaks in Europe …

African swine fever virus (ASFV) is a macrophage-tropic virus responsible for ASF, a
transboundary disease that threatens swine production world-wide. Since there are no …

The DNA genome of eukaryotic cells is compacted by histone proteins within the nucleus to
form chromatin. Nuclear‐replicating viruses such as adenovirus have evolved mechanisms …

In this study, we have identified a unique mechanism in which human cytomegalovirus
(HCMV) protein pUL79 acts as an elongation factor to direct cellular RNA polymerase II for …

How histone acetylation promotes transcription is not clearly understood. Here, we confirm
an interaction between p300 and the adenovirus 2 large E1A activation domain (AD) and …

In the ongoing arms race between virus and host, fine-tuned gene expression plays a critical
role in antiviral signaling. However, viruses have evolved to disrupt this process and …

Highlights•Pathogens exploit cellular functions to their own advantage to create an
environment conducive to their persistence and propagation.•Viruses and bacteria express …