Objectives One of the most frequently affected organs in mitochondrial disorders (MIDs),
defined as hereditary diseases due to affection of the mitochondrial energy metabolism, is …

Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality
worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the …

Cardiovascular involvement is highly prevalent among patients with pathogenic mtDNA
mutations. The relationship between CVD susceptibility and 'natural'mtDNA polymorphisms …

Progressive external ophthalmoplegia is a common clinical feature in mitochondrial disease
caused by nuclear DNA defects and single, large-scale mitochondrial DNA deletions and is …

Background The mitochondrial DNA (mDNA) 3243A> G variant is the most common
pathogenic variant of the mDNA. To interpret results of clinical trials in mitochondrial …

Abstract Purpose of Review Uncommon causes of stroke merit specific attention; when
clinicians have less common etiologies of stoke in mind, the diagnosis may come more …

Background Coronary heart disease (CHD) is the most common cause of mortality globally,
yet mitochondrial genetic mutations associated with CHD development remain incompletely …

Background Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes
(MELAS) is a common mitochondrial syndrome. The aim of this study was to conduct a …

Cardiovascular disease (CVD) is a world-wide cause of mortality in humans and its
incidence is on the rise in Africa. In this review, we discuss the putative role of mitochondrial …

Background Renal involvement in patients with the m. 3243A> G mutation may result in end-
stage renal disease (ESRD) requiring renal replacement therapy. Although kidney …