Efficient human promoter feature extraction is still a major challenge in genome analysis as
it can better understand human gene regulation and will be useful for experimental …

Core promoters are stretches of DNA at the beginning of genes that contain information that
facilitates the binding of transcription initiation complexes. Different functional subsets of …

The binding motifs of many transcription factors (TFs) comprise a higher degree of
complexity than a single position weight matrix model permits. Additional complexity is …

We present THiCweed, a new approach to analyzing transcription factor binding data from
high-throughput chromatin immunoprecipitation-sequencing (ChIP-seq) experiments …

Extraction of human promoter features is still a major obstacle in genome research but
knowing gene expression control is an essential part of understanding gene activity …

This thesis is divided into 5 chapters. In Chapter 1, the Introduction, we summarise the
necessary background to the work described in this thesis, including a discussion of major …

With rapid advances in experimental methods that map transcription start sites (TSSs) at a
high resolution, there is a need to characterize the sequence diversity of TSS …

In eukaryotic cells, the term chromatin describes DNA as found in vivo, where it binds to
scaffolding and other DNA-binding proteins as well as specific short RNA sequences. DNA …

Animal development is attributed to differential gene expression that is tightly regulated.
Genes are transcribed from core promoters, sequences of around 100 base pairs (bp) …