Through its actions on regulatory genes that form, grow and sculpt the brain, thyroid
hormone (TH) is essential for human brain development. Although much of what we know …

Animal models and epidemiological studies suggest that mild maternal thyroid hormone
deficiency in early gestation has adverse consequences on the cognitive abilities of the …

Background: Thyroid hormones are important for the adult brain, particularly regions of the
hippocampus including the dentate gyrus and CA1 and CA3 regions. The hippocampus is a …

Background: Rodents with gestational thyroid-hormone (TH) deficiencies and children with
congenital hypothyroidism show abnormal hippocampal development. Given that the human …

The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's
disease (AD) remain to date poorly understood. Epidemiologic studies in humans and …

Localising accurate brain regions needs careful evaluation in each experimental species
due to their individual variability. However, the function and connectivity of brain areas is …

Congenital hypothyroidism is associated with delay in cell migration and proliferation in
brain tissue, impairment of synapse formation, misregulation of neurotransmitters …

The hippocampus maintains a capacity for neurogenesis throughout life, a capacity that is
reduced in models of adult onset hypothyroidism. The effects of developmental thyroid …

Background Several investigations in recent years have reported a relationship between
hypothyroidism or ischemia and central nervous system (CNS) beginning from fetal to adult …

Thyroid hormones play a critical role in brain development but also in the adult human brain
by modulating metabolic activity. Hypothyroid states are associated with both functional and …