[HTML][HTML] Hybrid methods for combined experimental and computational determination of protein structure

JT Seffernick, S Lindert - The Journal of chemical physics, 2020 - pubs.aip.org
Knowledge of protein structure is paramount to the understanding of biological function,
developing new therapeutics, and making detailed mechanistic hypotheses. Therefore …

Small-angle neutron scattering contrast variation studies of biological complexes: Challenges and triumphs

S Krueger - Current opinion in structural biology, 2022 - Elsevier
Small-angle neutron scattering (SANS) has been a beneficial tool for studying the structure
of biological macromolecules in solution for several decades. Continued improvements in …

[图书][B] Small-angle scattering: theory, instrumentation, data, and applications

IW Hamley - 2021 - books.google.com
SMALL-ANGLE SCATTERING A comprehensive and timely volume covering contemporary
research, practical techniques, and theoretical approaches to SAXS and SANS Small-Angle …

Viewing SARS-CoV-2 nucleocapsid protein in terms of molecular flexibility

T Matsuo - Biology, 2021 - mdpi.com
Simple Summary Nucleocapsid protein is one of the essential proteins for viral replication
including the coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID …

A two-lane mechanism for selective biological ammonium transport

G Williamson, G Tamburrino, A Bizior, M Boeckstaens… - Elife, 2020 - elifesciences.org
The transport of charged molecules across biological membranes faces the dual problem of
accommodating charges in a highly hydrophobic environment while maintaining selective …

Combined small-angle X-ray and neutron scattering restraints in molecular dynamics simulations

P Chen, R Shevchuk, FM Strnad, C Lorenz… - Journal of chemical …, 2019 - ACS Publications
Small-angle X-ray and small-angle neutron scattering (SAXS/SANS) provide unique
structural information on biomolecules and their complexes in solution. SANS may provide …

Prokaryotic ammonium transporters: what has three decades of research revealed?

A Bizior, G Williamson, T Harris… - …, 2023 - microbiologyresearch.org
The exchange of ammonium across cellular membranes is a fundamental process in all
domains of life. In plants, bacteria and fungi, ammonium represents a vital source of …

Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations

G Williamson, A Bizior, T Harris, L Pritchard… - Bioscience …, 2024 - portlandpress.com
The exchange of ammonium across cellular membranes is a fundamental process in all
domains of life and is facilitated by the ubiquitous Amt/Mep/Rh transporter superfamily …

Coexistence of ammonium transporter and channel mechanisms in Amt-Mep-Rh Twin-His variants impairs the filamentation signaling capacity of fungal Mep2 …

G Williamson, AS Brito, A Bizior, G Tamburrino… - Mbio, 2022 - Am Soc Microbiol
Ammonium translocation through biological membranes, by the ubiquitous Amt-Mep-Rh
family of transporters, plays a key role in all domains of life. Two highly conserved histidine …

[PDF][PDF] Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme–substrate recognition

A Anandan, NW Dunstan, TM Ryan, HDT Mertens… - IUCrJ, 2021 - journals.iucr.org
Many pathogenic gram-negative bacteria have developed mechanisms to increase
resistance to cationic antimicrobial peptides by modifying the lipid A moiety. One …